In-vivo Evaluation of Blood Pumps
Despite intensive efforts to evaluate blood pumps in vitro (toxicologically, hydrodynamically, in respect to hemolysis and to thrombus generation, and simulation of physiological control) animal experiments are inevitable to test these complex devices before going into clinical evaluation and routinuous use. Within the Center for Biomedical Research, we have the facilities and experience to perform such tests as cautious as possible and with all the necessary monitoring of metabolic and hemodynamic parameters. With this experience we were already able to transfer a our Vienna Total Artificial Heart and the Vienna Assist Device into clinical use.Such tests are also necessary before introducing devices into the first clinical trial to get the surgical and control know-how for the appropriate use in humans.
- Online registration of a hemodynamics in an assist device experiment (Full continuous store of 32 channels up to 8 hours possible, Courtesy by HG Stöhr, CBR)
- Pressure and flow recording at a control variation
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Contact Persons:
Prof. Udo Losert, Center of Biomedical Research, Univ. of Vienna, Austria
Cooperating Institutions: Helmholtz Institute for Biomedical Engineering, Aachen, Germany
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References:
Linneweber J, Nonaka K, Takano T, Kawahito S, Schulte-Eistrup S, Motomura T, Ichikawa S, Mikami M, Stevens S, Schima H, Wolner E, Nose Y.
Hemodynamic exercise response in calves with an implantable biventricular centrifugal blood pump.
Artif Organs. 2001 Dec;25(12):1018-21
Schima, H., G. Wieselthaler, I. Schwendenwein, U. Losert, and E. Wolner. A review and assessment of investgative methods for mechanically induced blood trauma: special aspects in rotary blood pumps. In Akutsu, T. and H. Koyanagi, eds. Heart Replacement - Artificial Heart 6. Tokyo, Springer-Verlag. 1998, 361-369.
Schmidt, C., I. Schwendenwein, G. Wieselthaler, K. Roschal, H. Schima, U. Losert, and E. Wolner. Pharmacologically induced heart failure for the evaluation of circulatory assistance. Artif Organs 20: 685-688, 1996.
Holzer, S., R. Scherer, C. Schmidt, I. Schwendenwein, G. Wieselthaler, R. Noisser, and H. Schima. A clinical monitoring system for centrifugal blood pumps. Artif Organs 19: 708-712, 1995.
Schima, H., H. Schmallegger, L. Huber, I. Birgmann, C. Reindl, C. Schmidt, K. Roschal, G. Wieselthaler, W. Trubel, U. M. Losert, and E. Wolner. An implantable seal-less centrifugal pump with integrated double-disk motor. Artif Organs 19: 639-643, 1995.
Schima, H., W. Trubel, A. Moritz, G. Wieselthaler, H. Stoehr, H. Thoma, U. Losert, and E. Wolner. Noninvasive monitoring of rotary blood pumps: Necessity, possibilities and limitations. Artif.Organs Vol 16, Nr2: 195-202, 1992.
Losert, U., H. Siegl, H. Schima, and H. Stoehr. Hemodynamic changes during circulatory assist. In Rakhorst, G. and A. Hoekstra, eds. Proc. of the conc. action heart: veterinary aspects of animal experiments with heart assist devices. Bruxels, Commission of the EC. 1991, 55-61.
Moritz, A., L. Fujimoto, G. Wollenek, H. Schima, W. Schreiner, A. Windisch, U. Windberger, and U. Losert. Sustained heart failure induced by repeated microsphere injections for left ventricular assist device testing. ASAIO Transactions 35: 455-458, 1989.
Schima, H., W. Trubel, F. Coraim, L. Huber, M. R. Müller, G. Redl, U. Losert, H. Thoma, and E. Wolner. Control of the total artificial heart:New aspects in human versus animal experience. Artif.Organs Vol13,Nr6: 545-552, 1989.